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These outcomes align with the local effect theory

Cloning and sequencing of the cDNA for the light subunit of human liver g-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues

Besides, we assume sphincter failure as a hallmark of the ongoing injury, in contrast to some considerations about NO-sphincter relations (20), however, unrelated to injurious conditions (21-23)